Molecular Genetics of Clear-Cell Renal Cell Carcinoma
نویسندگان
چکیده
منابع مشابه
Molecular genetics of clear-cell renal cell carcinoma.
Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by frequent inactivation of the VHL gene (infrequently mutated in other tumor types), responsiveness to angiogenesis inhibitors, and resistance to both chemotherapy and conventional radiation therapy. ccRCC tumors exhibit substantial mutation heterogeneity. Recent studies using massively parallel sequencin...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2014
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2012.45.2003